Scientists have used a smartphone to control the activity of the living cells inside an animal.
The combination of biology and technology was used to control blood sugar levels in mice with diabetes (糖尿病). The idea could be applied to a wide range of diseases and drug treatments. The first step was to turn normal cells into living factories. They were genetically engineered to manufacture drugs that control blood sugar levels such as insulin (胰岛素) - but only in response to light. The technology is called optogenetics (光遗传学) and these cells would start to work when exposed to specific wavelengths of red light.
Then comes the tech—a set of wirelessly powered LEDs and a smartphone app to control them. Scientists implanted the system into mice and were able to control diabetes with the tap of a touchscreen. They said the findings could pave the way for a new era of personalised, digitalised and globalised precision medicine.
The scientists needed to take tiny drops of blood to know how high the blood sugar levels were, so they could calculate how much drug to release inside the animal. Their goal is a fully automated system that both detects sugar levels and then releases the right amount of chemicals for treatment.
This idea is clear at an early stage, but it is not limited to diabetes. Cells could be engineered to manufacture a wide range of drugs. Prof Mark Gomelsky said the study was an "exciting accomplishment". He added: "How soon should we expect to see people on the street wearing fashionable LED wristbands that shiny implanted cells engineered to produce genetically drugs under the control of a smartphone?" "Not just yet, but the work provides us with an exciting glimpse into the future of smart cell-based therapy."
